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In the modern health intervention field, Coenzyme Q10 (CoQ10) and Pyrroloquinoline Quinone (PQQ), as two quinone compounds with unique biological activities, have gradually attracted widespread attention. They not only play an important role in regulating metabolism and antioxidant defense but also show great potential in cardiovascular health, neuroprotection, and other aspects.
Coenzyme Q10 is a lipophilic compound widely present in the mitochondria of human cells and is crucial for cellular energy metabolism and antioxidant defense. As a potent antioxidant, CoQ10 can effectively neutralize excessive reactive oxygen species (ROS) in the body, reduce oxidative stress, and thus protect cells from oxidative damage. This property enables it to play an important role in cardiovascular health by improving vascular endothelial function, lowering blood pressure, and regulating blood lipid levels, thereby reducing the risk of cardiovascular diseases. In addition, CoQ10 is involved in the energy metabolism process of mitochondria, enhancing the efficiency of cellular energy production, which is of great significance for maintaining normal cellular functions.
Despite the many benefits of CoQ10, its low bioavailability has limited its widespread application. In recent years, the development of advanced formulation technologies such as nanotechnology has provided new ways to improve the bioavailability of CoQ10. For example, by formulating CoQ10 into nanoemulsions or combining it with liposomes, its absorption rate in the intestines and stability in the body can be significantly increased, thereby enhancing its therapeutic effects.
PQQ is a water-soluble quinone compound widely found in nature and has attracted much attention in recent years due to its unique biological activities. PQQ has strong antioxidant capacity and can effectively scavenge free radicals in the body, reduce oxidative stress, and provide positive protection for human health. In addition, PQQ is involved in the energy metabolism process of mitochondria. By regulating mitochondrial function, it enhances the efficiency of cellular energy production, thereby improving the metabolic state of cells. Studies have shown that PQQ can regulate the activity of various enzymes related to metabolism, thereby affecting the processes of gluconeogenesis and glycolysis, which helps maintain the body's metabolic balance.
In terms of neuroprotection, PQQ also shows great potential. PQQ can regulate the metabolism and function of nerve cells and has a certain protective effect on neurodegenerative diseases. In addition, PQQ can also reduce inflammatory responses and has a certain preventive effect on inflammation-related diseases in the body.
With the continuous in-depth research and technological progress, CoQ10 and PQQ are expected to become important adjuvants in health promotion and bring more health benefits to people.
Zhang T, Li M, Lu J, et al. Insights into the Sources, Structure, and Action Mechanisms of Quinones on Diabetes: A Review[J]. Molecules, 2025, 30(3): 665.
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