Studies have found that NMN supplementation can improve symptoms of dry mouth aging

Humans secrete 0.5 to 1.5 liters of saliva per day, which performs self-cleaning, digestion, pH buffering and antibacterial functions to maintain a normal oral environment.

With age, the body's saliva production gradually decreases, resulting in a dry mouth that makes swallowing difficult and increases the risk of aspiration pneumonia.

There is no effective treatment for dry mouth caused by aging.

In December 2024, The research team from Japan published a paper titled "Nicotinamide Mononucleotide suppresses cellular senescence and increases aquaporin 5" in the journal Biogerontology expression in the submandibular gland of aged male mice to ameliorate aging-related dry mouth ".

The study found that older mice treated with NMN had increased levels of both salivary secretion and NAD+ in the submandibular gland.

The levels of submaxillary gland acetylation, senescent cell number and senescence related secretion phenotype (SASP) factors decreased in aged mice treated with NMN, while the mRNA expression of aquaporin 5 (AQP5) increased.

NMN therapy can improve dry mouth by regulating the aging of submandibular gland cells and increasing the expression of AQP5, a water channel involved in salivary secretion.

The researchers first found that in the control group that received the saline treatment, the total saliva production and saliva flow rate of the older mice were significantly lower than that of the younger mice.

The total salivary production and saliva flow rate of the older mice treated with NMN were comparable to those of the younger mice treated with saline.

The level of NAD+ in the submandibular gland of elderly mice in the normal saline treatment group was significantly lower than that of young mice, and NMN treatment could increase the level of NAD+ in the submandibular gland of elderly mice to the level of young mice.

The expression level of p21 in the submandibular gland of aged mice is significantly higher than that of young mice, and p21 is a common indicator of aging.

Further studies showed that NMN treatment reduced p21 expression in older mice to levels similar to those in younger mice.

Importantly, NMN treatment also reduced SA-beta-gal activity to levels seen in young mice.

The researchers found that after NMN treatment in older mice, the expression level of aquaporin 5 (AQP5) gene increased to that of younger mice, which enhanced salivation.

The study found that NMN treatment improved dry mouth by regulating the aging of submandibular gland cells and increasing the expression of AQP5, a water channel involved in salivary secretion.

References:

https://link.springer.com/article/10.1007/s10522-024-10162-2

by GSHWORLD

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