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Acne vulgaris is a highly prevalent skin condition caused by multiple factors, including androgen-induced increased sebum secretion, abnormal keratinization, bacterial colonization, and inflammation. Studies have shown a link between acne vulgaris and metabolic syndrome, a group of diseases that includes obesity, insulin resistance, hypertension, and dyslipidemia.
This link is thought to be mediated by excessive concentrations of oxidative stress markers and chronic inflammation, which are pathophysiological mechanisms shared by both diseases.
Glutathione is an important component of the skin's antioxidant defense system. Together with enzymes such as glutathione peroxidase (GPX), glutathione reductase (GR), and superoxide dismutase (SOD), it maintains the redox balance of cells.
In some studies, glutathione levels are negatively correlated with the severity of acne, that is, reduced glutathione levels are associated with increased acne severity.
Glutathione can effectively scavenge oxygen free radicals, neutralize reactive oxygen species (ROS), and promote the regeneration of damage caused by ROS.
In addition to its antioxidant potential, glutathione is also involved in a variety of biological processes such as the removal of foreign bodies, the control of redox signaling, the regulation of cell growth and immune response.
Depletion of glutathione increases oxidative stress and is considered an important factor in the development of a variety of clinical diseases.
In terms of treatment, studies have suggested that glutathione supplementation may help improve the antioxidant capacity of patients with acne vulgaris and may be beneficial in the management of acne patients, especially those with reduced GPX activity, together with vitamin E and selenium supplementation.
The combination of glutathione with vitamin C and zinc shows promise in the treatment of acne, especially in enhancing skin elasticity, pigmentation and smoothness.
This information suggests that glutathione plays an important role in the pathogenesis and treatment of acne vulgaris. Changes in its level are associated with the severity of acne and may be used as an auxiliary treatment.
[1] Bungau A F, Radu A F, Bungau S G, et al. Oxidative stress and metabolic syndrome in acne vulgaris: Pathogenetic connections and potential role of dietary supplements and phytochemicals[J]. Biomedicine & Pharmacotherapy, 2023, 164: 115003.
