With the advancement of modern medicine, people around the world are living longer. At the same time, in addition to reducing mortality and improving survival rates, declining fertility rates have also led to an increase in the proportion of the elderly population. According to the World Health Organization, the global elderly population is expected to reach 2.1 billion by 2050, and the elderly population will double.
However, a longer life does not guarantee a healthy life. As we age, our organs accumulate damage and gradually decline, making us susceptible to disease. Therefore, many scientists have begun to focus on ways to slow down, prevent or even reverse aging. If successful, so-called anti-aging treatments could reduce the prevalence of age-related diseases and help us live healthier lives longer.
Currently, one of the most promising anti-aging targets is an important molecule called nicotinamide adenine dinucleotide (NAD+). NAD+ plays a mediating role in the production of energy needed for cell function and survival, providing fuel for key enzymes that repair DNA damage.
NMN is the precursor of NDA+. Unlike NAD+ itself, NMN can be taken orally to supplement and increase NAD+ levels.
NMN’s four major health benefits:
1. Delay aging
The core role of NMN in anti-aging is to promote the conversion and improvement of NAD+, and NAD+ plays an important role in improving the aging state of the human body and delaying aging. As the direct precursor of NAD+, NMN can exert its effect by converting into NAD+. After taking NMN orally, the substance can enter the blood within 2-3 minutes, and be absorbed by body organs within 30 minutes, converting it into NAD+, increasing its content, and then using the influence of NAD+ on the body to produce effects in the human body.
2. Promote organ health
In addition to slowing aging in areas such as the brain, vascular system, muscles, heart, metabolism and eyes, NMN has been shown to rejuvenate bone marrow stem cells and promote bone formation in rodents. It also reverses intestinal aging, prevents age-related kidney degeneration, and inhibits the development of liver fibrosis in rodents. Therefore, NMN can also slow down the aging of bones, intestines, kidneys and liver.
3. Treat eye aging and damage
Macular degeneration is an age-related disease that involves the degeneration of areas of the retina, affecting our clear vision. Severe macular degeneration can even lead to blindness. Studies have shown that NMN can repair mitochondrial dysfunction associated with macular degeneration in mice.
As we age, our eyes can become dry and inflamed. Research shows that NMN can reduce inflammation and increase oil production to relieve and treat dry eye syndrome. In addition, NMN reduces cell death and wound size after eye injury.
4. Enhance DNA repair and maintenance
Our DNA coding makes up part of our cells, but as we age, it becomes cumulatively damaged. Repairing DNA damage may prevent age-related diseases. NAD+ provides energy for a class of enzymes called sirtuins, which are sometimes considered the guardians of our healthy lifespan. Sirtuins play a key role in DNA repair.
Additionally, every time a cell divides, the DNA at the ends of chromosomes, called telomeres, gets shorter. At some point, this telomere shortening can damage our genes and cells. Sirtuins slow this process by stabilizing telomere length.
Since sirtuins rely on NAD+ to function, people have been working hard to enhance sirtuin activity by increasing NAD+. Research shows that feeding NMN to mice activates sirtuins. In addition, NMN can also repair DNA damage caused by radiation and aging in mice. Furthermore, NMN increases telomere length in both mice and humans.
*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.