The relationship between NMN and NAD+

by: GSHWORLD Time: 2023-12-15 Classify: Product News

NMN is a ribonucleotide, the basic structural unit that constitutes the genetic material RNA.

It is composed of nicotinamide group, ribose and phosphate group.

NMN is converted into NAD+ (nicotinamide adenine dinucleotide) in cells to play its role.

NAD is not only the core of energy metabolism in the human body, but also serves as a key signaling molecule and a coenzyme for various enzymes (more than 300 enzymes rely on NAD+ to work), participating in DNA repair, chromatin remodeling, cell aging and strengthening immunity. system.

In addition, NAD can also activate the "longevity protein" Sirtuins and regulate their gene expression, thereby reducing the occurrence of diseases and delaying aging.

Although NAD+ is present in some foods, due to its low content, diet alone cannot affect intracellular NAD+ levels.

Taking NMN supplements has been proven to be a direct and effective way to increase NAD+ levels.

NMN can be directly converted into NAD+ in the body and is more easily absorbed and utilized by cells.

Therefore, NMN supplements have become the first choice for increasing NAD+ levels in the body.

In animal studies, NAD+ supplements (NMN) have significant effects on improving metabolism and age-related diseases (such as cardiovascular disease, diabetes, neurodegenerative diseases, and reduced immune function) by increasing NAD+ levels in the body, and have demonstrated inhibitory effects Characteristics of aging.

As an essential coenzyme in the redox process, NAD+-dependent adenosine diphosphate ribosyltransferase, ring-sourced ADP-ribose polymerase, and type III histone deacetylase, the only substance that can be used, participates in cell material metabolism, energy Synthesis, cell DNA repair and other physiological activities.

NAD+ and circadian clock regulation

Biological clock regulation is closely related to many diseases, including sleep disorders, diabetes, tumors, etc.;

the occurrence and development of many diseases are triggered by circadian clock disorders.

There are many factors for the disorder of the biological clock, which may come from genetics or the environment.

Keeping the normal work of the biological clock plays an extremely critical role in maintaining the health of the body and delaying aging.

Studies have found that NAD+ regulates the biological clock through SIRT1:

the NAD+-dependent deacetylase SIRT1 establishes a bridge between circadian rhythm and metabolism by regulating the enzyme feedback loop of the NAD+ salvage pathway.

SIRT1 antagonizes the acetylation function of CLOCK by deacetylating BMAL1 and PER2, thereby inhibiting the transcription of clock genes mediated by CLOCK-BMAL1.

Therefore, NAD+ affects the deacetylation activity of SIRT1 through its own content level, which in turn affects the expression of a series of circadian clock-related proteins including NAMPT.

As the precursor of NAD+, NMN can significantly increase the NAD+ content in the body, thereby delaying, improving, and preventing various aging-related manifestations, as well as metabolic disorders and senile diseases caused by age.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.