Various effects of S-adenosylmethionine

 

Adenosylmethionine is an important coenzyme in the human body and the active form of methionine in the organism.

Adenosylmethionine is synthesized from methionine and adenosine triphosphate catalyzed by adenosylmethionine synthase in the organism. It can be used as a methyl donor, a sulfur group donor and an aminopropyl group donor in biological metabolism. Adenosylmethionine participates in various metabolisms through transmethylation, transsulfurization and transaminopropylation.

In addition, adenosylmethionine, as the most important methyl donor in the body, is also involved in the methylation modification of nucleic acids and proteins, such as the methylation of the amino groups of bases on the RNA chain and the hydroxyl groups of ribose. Adenosylmethionine can also promote the biosynthesis of membrane phospholipids, increase membrane fluidity, and accelerate bile acid transport in the body.

At the same time, adenosylmethionine is also an active precursor of sulfur-containing compounds such as cysteine and glutathione. The synthesis of many important polyamines in the body, such as spermidine and spermine, also requires the transamination of adenosylmethionine. Propyl effect.

Studies have shown that the adenosyl methionine metabolic pathway in patients with liver transplantation and early liver cancer can be further strengthened and promote liver cell regeneration through the transaminopropyl effect of adenosyl methionine. Therefore, clinically supplementing adenosylmethionine is of great significance for patients with liver disease.

Adenosylmethionine is currently also widely used in the treatment of various liver diseases, such as intrahepatic cholestasis. At the same time, because it can promote the production of neurotransmitters, it can also significantly improve depression associated with liver diseases. Adenosylmethionine can also induce gene hypermethylation, reverse overall hypomethylation, inhibit gene expression in tumor tissues, reduce tumor invasiveness, and delay distant metastasis of tumors. It has good prospects for the prevention and treatment of tumors.

Data source: Fan Yiqiao. Research progress on clinical application of adenosylmethionine [J]. World Clinical Drugs, 2017, 38(05): 364-368. DOI: 10.13683/j.wph.2017.05.016.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.