NMN and eye diseases

 

Photoreceptor degenerative diseases are primarily age-related eye diseases that lead to severe visual impairment or irreversible vision loss, including age-related macular degeneration, diabetic retinopathy, and retinal detachment (RD). However, in currently available human clinical trials, no pharmacological approach has been shown to be effective in treating photoreceptor degeneration.

Nicotinamide adenine dinucleotide (NAD+) is a cofactor in redox metabolism and is essential for energy production. In recent years, NAD+ decline has been found in various diseases. Enhanced NAD+ biosynthesis is beneficial for age-related metabolic and neurodegenerative diseases, and several papers have also reported the application of NAD+ biosynthesis in eye diseases.

However, little is known about the role of NAD+ in photoreceptor detachment from the RPE and whether NAD+ and SIRT1 may play a role in protecting photoreceptors during detachment from the underlying RPE.

A research team from Harvard University published a study in the journal "aging" on the effects of enhancing NAD+ on the retina and photoreceptors after inducing RD.

The research team used NMN, the precursor of NAD+, to supplement the NAD+ content in mice. By studying the role of NMN in the degeneration of photoreceptor cells caused by retinal detachment (RD), they found that NMN was used to intervene immediately after retinal detachment (RD). , can effectively increase the activity of photoreceptor cells, reduce the activation of CD11b + macrophages and GFAP-labeled glial cells; the protein carbonyl content (PCC) tends to be standardized, and the thickness of the outer nuclear layer (ONL) is effectively maintained.

Moreover, the use of NMN can significantly increase the NAD+ level in relevant cells, and SIRT1 protein and heme oxygenase 1 (HO-1) also tend to be active. Even delayed use of NMN after retinal detachment (RD) provides similar protection. It can be seen that NMN anti-aging supplements do have a certain intervention and therapeutic effect on eye problems caused by retinal detachment and photoreceptor cell degeneration.

References: Chen mononucleotide (NMN) in a photoreceptor degenerative model of retinal detachment. Aging (Albany NY). 2020 Dec 29;12(24):24504-24521. doi: 10.18632/aging.202453. Epub 2020 Dec 29. PMID: 33373320; PMCID : PMC7803565.

*Special note - This article is for informational purposes only and cannot replace a doctor's treatment diagnosis and advice. It should not be regarded as a recommendation or proof of efficacy of the medical products involved. If it involves disease diagnosis, treatment, and rehabilitation, please be sure to go to a professional medical institution to seek professional advice.