Six benefits of NMN on heart and brain vessels

by: GSHWORLD Time: 2024-10-16 Classify: Technological Innovation

Cardiovascular and cerebrovascular disease is a serious threat to people's health, but also more and more attention, today Xiaobian to you summarized the 6 major benefits of NMN on cardiovascular and cerebrovascular.

1. Improve vascular endothelial function

Promoting nitric oxide synthesis, nitric oxide (NO) produced by vascular endothelial cells is essential for maintaining vasodilation and normal blood pressure.

NMN can promote NO synthesis by increasing intracellular NAD+ level and activating endothelial nitric oxide synthase eNOS.

Sufficient NO can relax vascular smooth muscle, dilate blood vessels, reduce blood flow resistance, improve blood circulation throughout the body, and reduce the afterload of the heart, which is very beneficial to cardiovascular health.

2. Reduce oxidative stress damage

With age, the level of oxidative stress in the cardiovascular and cerebrovascular systems increases, leading to excessive production of reactive oxygen species (ROS) within cells.

NMN activates antioxidant-related enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px)

These enzymes can clear intracellular ROS, reduce oxidative stress on vascular endothelial cells, cardiomyocytes and other damage, so as to protect the structure and function of the cardiovascular and cerebrovascular system.

3. Reduces inflammation

Inhibiting inflammatory factors and releasing chronic inflammation plays an important role in the occurrence and development of cardiovascular and cerebrovascular diseases.

NMN can regulate inflammatory signaling pathways such as inhibiting the activity of nuclear factor-KB (NF-KB).

Inhibition of NF-KB can reduce the release of tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6) and other inflammatory factors, thereby reducing the inflammatory response of blood vessel walls and reducing the risk of cardiovascular and cerebrovascular diseases such as atherosclerosis.

4. Improve lipid metabolism

Regulation of lipid synthesis and transport of NMN can affect gene expression and enzyme activity related to lipid metabolism.

It regulates the levels of fatty acid binding protein (FABP) and fatty acid transporter (FATP) in the liver, reducing fatty acid uptake and synthesis.

At the same time, NMN can also promote the synthesis of high density lipoprotein (HDL), which helps to transport cholesterol in the blood vessel wall to the liver for metabolism, thereby reducing the level of low density lipoprotein (LDL) and triglycerides in the blood, reducing the deposition of blood lipids in the blood vessel wall to prevent atherosclerosis.

5. Enhance myocardial function

Increase myocardial energy, metabolism Cardiomyocytes need a lot of energy to maintain normal systolic and diastolic functions.

NMN improves mitochondrial function, which is the main source of energy for heart muscle cells.

By increasing the level of NAD+, NMN can enhance the oxidative phosphorylation capacity of mitochondria and increase the production of ATP, thus providing more adequate energy for cardiomyocytes, enhancing myocardial contractility and improving cardiac function.

6. Inhibit platelet aggregation

Regulating platelet activity, excessive platelet aggregation is easy to form thrombosis, blocking blood vessels, causing cardiovascular and cerebrovascular events.

NMN can regulate signaling pathways within platelets and reduce platelet activity.

Inhibit platelet aggregation, reduce the risk of thrombosis, and help maintain smooth blood flow in the cardiovascular and cerebrovascular system.

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