Summary of studies on NMN in cardiac protection

by: GSHWORLD Time: 2024-10-15 Classify: Technological Innovation

Heart health has been the focus of NMN research in recent years.

NMN can improve the NAD+ homeostasis of the heart, alleviate the age-related cardiac pathological and physiological changes, and improve a variety of heart health problems.

study of NMN in cardiac protection

2014 New Jersey Medical School study

Intraperitoneal injection of NMN in mice significantly increased the level of NAD+ in the heart, prevented the decrease of NAD+ during ischemia, and protected the heart from ischemia/reperfusion injury, which is an important cause of heart failure.

2017 Case Western Reserve University School of Medicine study

Short-term intraperitoneal injection of NMN was able to protect mice from heart failure caused by stress overload because NMN protected the ultrastructure of mitochondria, reduced reactive oxygen species levels, and prevented heart cell death.

2020, Department of Laboratory Medicine and Pathology, University of Washington

The effects of SS-31 and NMN were tested, and SS-31 partially reversed age-related diastolic decline, while NMN completely reversed age-related cardiac systolic dysfunction.

Study of West China Hospital of Sichuan University in 2021

Intraperitoneal injection of NMN in mice with cardiac fibrosis can effectively enhance NAD+ and SIRT1, thereby alleviating cardiac fibrosis.

A study in the second half of 2021 showed that NMN has an effect on the autonomic regulatory function of the heart.

It can regulate the balance of the sympathetic and parasympathetic nerves in the heart and avoid heart disorders caused by nerve imbalances, such as too fast or too slow a heartbeat.

In April 2022, a research team from the Children's Hospital of Fudan University and the School of Life Sciences published research results in JACC (Journal of the American College of Cardiology):

NMN can effectively inhibit heart dysfunction caused by Echs1 deficiency.

Nicotinamide Mononucleotide Alleviates Cardiomyopathy Phenotypes Caused by Short-Chain Enoyl-Coa Hydratase 1 Deficiency

Cardiomyopathy is a polygenic disease, some of the world's children and adults suffer from this disease, may also be caused by a variety of factors, not only affect life and work and can not be cured, seriously can lead to heart failure.

Echs1 is a key enzyme in the oxidation of fatty acids and branched-chain amino acids, and its deficiency leads to cardiac fibrosis in mice.

Mice with Echs1 gene deficiency were fed a high-NMN diet from week 3 to week 8, and left ventricular systolic function was significantly restored at week 8, and cardiac fibrosis was significantly reduced after taking NMN.

NMN increases Echs1 in the heart, binds to p300 in the cytoplasm, reduces the transfer of p300 to the nucleus, and controls chromatin H3K9 acetylation by stimulating the enzyme SIRT, thereby inhibiting myocardial disease caused by Esch1 deficiency.

A study at the end of 2022 noted that NMN has a positive effect in improving microvascular function in the heart.

It can promote the proliferation and migration of microvascular endothelial cells, enhance the integrity and permeability of microvessels, and ensure that the heart tissue gets adequate oxygen and nutrients.

In 2023, a research institution found that NMN can maintain the normal electrophysiological activity of cardiomyocytes by regulating certain ion channels in cardiomyocytes, further reducing the risk of arrhythmia, and providing more comprehensive protection for heart health.

In early 2024, a new study showed that NMN may interact with a new type of protein inside heart cells, and this interaction helps to enhance the anti-stress ability of heart cells.

In an experimental setting that mimics heart disease, this interaction can reduce the damage to heart cells, providing new potential targets for the treatment of heart disease.

Research in mid-2024 found that NMN is involved in the regulation of a specific metabolic pathway within heart cells, and by optimizing this metabolic pathway, it can improve the efficiency of energy use by heart cells, thereby improving heart function.

This finding provides a new perspective for understanding the protective mechanism of NMN on the heart.

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