News

Research from Sichuan University shows that NAD+ is indispensable for stem cells from bone marrow to repair fractures.

On April 11, 2022, Japan completed a placebo-controlled, randomized, double-blind, parallel-group trial to investigate the safety of oral NMN and its efficacy in increasing NAD+ levels in 30 healthy subjects.

As the main antagonist of intracellular reactive oxygen species, glutathione also has important functions in the maintenance and regulation of stem cell functions.

Researchers from Zhejiang University School of Medicine show that the NAD+ precursor NMN enhances the ability of brain cells to generate myelin — the protective insulation coating nerve projections — in naturally and prematurely aged mice.

NMN is widely found in natural foods and is found in vegetables, fungi, meat, and shrimp (see Table 1). Ummarino et al. also found that NMN exists in human milk and donkey milk through a new enzyme coupling technology,

Nicotinamide mononucleotide (NMN) has a variety of biological functions, which are useful for heart and brain diseases, senile degenerative diseases,

Cholesterol metabolism homeostasis plays an important role in maintaining normal life activities, and blood cholesterol levels that are too low or too high will have adverse effects on the human body.

Scientists find that boosting NAD+ with NMN and NR supplementation alleviates diabetes-related nerve fiber degeneration and loss in rodents.

Tumor has become a very important medical research problem due to its complex mechanism. glutathione can also affect the survival of cancer stem cells by participating in regulation of some signaling molecules.

In recent years, the role of glutathione in regulating stem cell differentiation by participating in the energy metabolism of stem cells has become increasingly clear.

Preclinical studies suggest that elevations in nicotinamide adenine dinucleotide (NAD+) following administration of the NAD++ precursor nicotinamide mononucleotide (NMN) can alleviate aging-related diseases;

Glutathione is a tripeptide compound found in all living cells and is a combination of glutamic acid, cystine and glycine.

Nicotinamide mononucleotide (NMN)-treated antitumor CAR-T cells display enhanced effectiveness to combat cancer cells and reduce tumor growth in mice.

In addition to the damage protection of stem cells, reduced glutathione is also closely related to the immune regulation function of stem cells.

Glutathione can prevent the damage of stem cells and promote the self-renewal of stem cells as a potential activation signal in the early stage of apoptosis.

The redox state of stem cells is jointly determined by reactive oxygen species and the cellular antioxidant system. When the production of reactive oxygen species exceeds the processing capacity of

Nicotinamide mononucleotide (NMN)-treated antitumor immune cells display enhanced and sustained effectiveness to combat cancer cells and reduce tumor growth in mice.

In recent years, there have been more and more human clinical trials for NMN, and many feedbacks worthy of reference have been obtained.

Stroke is an acute cerebrovascular disease caused by cerebral blood circulation disorder, which has high mortality and morbidity, and seriously threatens human health. Studies have found that NMN can protect

Researchers from the Washington University School of Medicine in St. Louis show that the enzyme behind NMN biosynthesis – NAMPT – reversion metabolic derangements in obese mice.